1I heard a loud voice out of the temple, saying to the seven angels, “Go and pour out the seven bowls of the wrath of God on the earth!”
2The first went, and poured out his bowl into the earth, and it became a harmful and painful sore on the people who had the mark of the beast, and who worshiped his image.
3The second angel poured out his bowl into the sea, and it became blood as of a dead man. Every living thing in the sea died.
4The third poured out his bowl into the rivers and springs of water, and they became blood. 5I heard the angel of the waters saying, “You are righteous, who are and who were, O Holy One, because you have judged these things. 6For they poured out the blood of saints and prophets, and you have given them blood to drink. They deserve this.”
7I heard the altar saying, “Yes, Lord God, the Almighty, true and righteous are your judgments.”
8The fourth poured out his bowl on the sun, and it was given to him to scorch men with fire. 9People were scorched with great heat, and people blasphemed the name of God who has the power over these plagues. They didn’t repent and give him glory.
10The fifth poured out his bowl on the throne of the beast, and his kingdom was darkened. They gnawed their tongues because of the pain, 11and they blasphemed the God of heaven because of their pains and their sores. They still didn’t repent of their works.
12The sixth poured out his bowl on the great river, the Euphrates. Its water was dried up, that the way might be prepared for the kings that come from the sunrise. 13I saw coming out of the mouth of the dragon, and out of the mouth of the beast, and out of the mouth of the false prophet, three unclean spirits, something like frogs; 14for they are spirits of demons, performing signs, which go out to the kings of the whole inhabited earth, to gather them together for the war of that great day of God the Almighty.
15“Behold, I come like a thief. Blessed is he who watches, and keeps his clothes, so that he doesn’t walk naked, and they see his shame.” 16He gathered them together into the place which is called in Hebrew, “Harmagedon”.
17The seventh poured out his bowl into the air. A loud voice came out of the temple of heaven, from the throne, saying, “It is done!” 18There were lightnings, sounds, and thunders; and there was a great earthquake such as has not happened since there were men on the earth—so great an earthquake and so mighty. 19The great city was divided into three parts, and the cities of the nations fell. Babylon the great was remembered in the sight of God, to give to her the cup of the wine of the fierceness of his wrath. 20Every island fled away, and the mountains were not found. 21Great hailstones, about the weight of a talent, came down out of the sky on people. People blasphemed God because of the plague of the hail, for this plague was exceedingly severe.
The "wine" spoken of in this passage is with little doubt fermented since the word is oinos (οἶνος), a translation of the Hebrew word yayin (יַ֜יִן). The word for "grape juice" (thus not fermented) is trux (τρύξ), a word not found in the New Testament. The limited use of grape juice may relate to the rapid fermentation of grape juice in the climate of Israel. It was common, however, to mix two to three parts water with wine in the first century, a practice that came from Greece with the Hellenizing influence that came from Alexander the Great's entrance into Semitic culture in the middle of the 4th century B.C. This was largely done in order to lessen the cost of wine rather than for sterilizing the water, which is sometimes posited as the reason.
You may read a more extensive study of wine in my article on wine at [H. Wayne House], "Wine," Baker Encyclopedia of the Bible, Vol 2, J-Z, Walter A. Elwell, Gen. Ed. (Grand Rapids, MI: Baker Book House), 2145-2148.